Cyclopropylamine → HCID 66747662, compound

HRID 1469023Notes

Reaction equation

HRID 1469023 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([O:19]CC)=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH3:29].[CH:30]1([NH2:33])[CH2:32][CH2:31]1>>[CH:30]1([NH:33][C:6]2[C:5]3[C:10](=[CH:11][C:2]([F:1])=[C:3]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[CH:4]=3)[N:9]=[C:8]([N:12]3[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[CH:14]=[N:13]3)[N:7]=2)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 136379422HCID 136379422, compound

Product 1

HCID 66747662HCID 66747662, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(7-fluoro-4-oxo-6-(o-tolyl)-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and cyclopropyl amine in step E. MS (ESI): predicted mass calcd. for C22H18FN5O2, 403.1

Sources & evidence

ORD record
ord-1d3f7d485b9b4e47b9f9feb64f31ea9f
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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