Cyclopropylamine → HCID 56655849, compound

HRID 1469029Notes

Reaction equation

HRID 1469029 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([O:19]CC)=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[CH:23]([CH3:25])[CH3:24].[CH:26]1([NH2:29])[CH2:28][CH2:27]1>>[CH:26]1([NH:29][C:6]2[C:5]3[C:10](=[CH:11][C:2]([F:1])=[C:3]([CH:23]([CH3:25])[CH3:24])[CH:4]=3)[N:9]=[C:8]([N:12]3[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[CH:14]=[N:13]3)[N:7]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 136379411HCID 136379411, compound

Product 1

HCID 56655849HCID 56655849, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(7-fluoro-6-isopropyl-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and cyclopropyl amine in step E. MS (ESI): predicted mass calcd. for C18H18FN5O2, 355.1

Sources & evidence

ORD record
ord-a9401ebb2733471ab2aad8f894292697
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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