Cyclopropylamine → HCID 66747970, compound

HRID 1469035Notes

Reaction equation

HRID 1469035 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([O:19]CC)=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.[CH:29]1([NH2:32])[CH2:31][CH2:30]1>>[CH:29]1([NH:32][C:6]2[C:5]3[C:10](=[CH:11][C:2]([F:1])=[C:3]([N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)[CH:4]=3)[N:9]=[C:8]([N:12]3[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[CH:14]=[N:13]3)[N:7]=2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 136379423HCID 136379423, compound

Product 1

HCID 66747970HCID 66747970, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(7-fluoro-4-oxo-6-(piperidin-1-yl)-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and cyclopropylamine in step E. MS (ESI): predicted mass calcd. for C20H21FN6O2, 396.2

Sources & evidence

ORD record
ord-05a92febc00144459ea559445978786c
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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