Cyclopropylamine → HCID 66747738, compound

HRID 1469064Notes

Reaction equation

HRID 1469064 reaction equation
[CH3:1][C:2]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([N:16]1[CH:20]=[C:19]([C:21]([O:23]CC)=[O:22])[CH:18]=[N:17]1)[NH:10][C:9]2=O.[CH:32]1([NH2:35])[CH2:34][CH2:33]1>>[CH3:1][C:2]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([N:16]1[CH:20]=[C:19]([C:21]([OH:23])=[O:22])[CH:18]=[N:17]1)[N:10]=[C:9]2[NH:35][CH:32]1[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 136379407HCID 136379407, compound

Product 1

HCID 66747738HCID 66747738, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-((2,6-dimethylbenzyl)amino)-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and cyclopropylamine in step E. MS (ESI/CI): predicted mass C24H24N6O2, 428.2.

Sources & evidence

ORD record
ord-01249810c55742f79ad072403624b6a9
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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