Morpholine → HCID 66747364, compound

HRID 1469066Notes

Reaction equation

HRID 1469066 reaction equation
[C:1]1([CH3:28])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([N:17]1[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]1)[NH:11][C:10]2=O.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[O:32]1[CH2:33][CH2:34][N:29]([C:10]2[C:9]3[C:14](=[CH:15][CH:16]=[C:7]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=4[CH3:28])[CH:8]=3)[N:13]=[C:12]([N:17]3[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]3)[N:11]=2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 136337162HCID 136337162, compound

Product 1

HCID 66747364HCID 66747364, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-(o-tolyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and morpholine in step E. MS (ESI/CI): predicted mass C23H21N5O3, 415.2.

Sources & evidence

ORD record
ord-298fd940fc254586a9ccfc79370c140d
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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