Morpholine → HCID 66747365, compound

HRID 1469072Notes

Reaction equation

HRID 1469072 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[C:12]([N:17]2[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]2)[NH:11][C:10]3=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[O:31]1[CH2:32][CH2:33][N:28]([C:10]2[C:9]3[C:14](=[CH:15][CH:16]=[C:7]([N:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)[CH:8]=3)[N:13]=[C:12]([N:17]3[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]3)[N:11]=2)[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 136379412HCID 136379412, compound

Product 1

HCID 66747365HCID 66747365, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-(piperidin-1-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and morpholine in step E. MS (ESI/CI): predicted mass C21H24N6O3, 408.2.

Sources & evidence

ORD record
ord-831f9fe51aee41f483f53cb33b55935f
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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