Cyclopropylamine → HCID 66747495, compound

HRID 1469076Notes

Reaction equation

HRID 1469076 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[C:12]([N:17]2[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]2)[NH:11][C:10]3=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:28]1([NH2:31])[CH2:30][CH2:29]1>>[CH:28]1([NH:31][C:10]2[C:9]3[C:14](=[CH:15][CH:16]=[C:7]([N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)[CH:8]=3)[N:13]=[C:12]([N:17]3[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]3)[N:11]=2)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 136379412HCID 136379412, compound

Product 1

HCID 66747495HCID 66747495, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-(piperidin-1-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and cyclopropylamine in step E. MS (ESI/CI): predicted mass C20H22N6O2, 378.2.

Sources & evidence

ORD record
ord-ff74f4d86ee546bda84f5f39b02923d3
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

Loading…