N-Methylethylamine → HCID 66747463, compound

HRID 1469077Notes

Reaction equation

HRID 1469077 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[C:12]([N:17]2[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]2)[NH:11][C:10]3=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:28]([NH:30][CH3:31])[CH3:29]>>[CH2:28]([N:30]([CH3:31])[C:10]1[C:9]2[C:14](=[CH:15][CH:16]=[C:7]([N:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[CH:8]=2)[N:13]=[C:12]([N:17]2[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]2)[N:11]=1)[CH3:29]

Participants

3

Reactant 2

HCID 12219N-MethylethylamineHCID 136379412HCID 136379412, compound

Product 1

HCID 66747463HCID 66747463, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-(piperidin-1-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and N-ethyl-N-methylamine in step E. MS (ESI/CI): predicted mass C20H24N6O2, 380.2.

Sources & evidence

ORD record
ord-4ef21fd7024646db9402d0b2833f6c3c
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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