反应详情

0.19 g of 4-(2,3-dihydroindol-1-yl)-6-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]-pyridin-5-yl)quinazoline and 0.08 g of caesium fluoride in 1 ml of acetonitrile are stirred at 25° C. in a flask until the reaction is complete (HPLC check, about 24 hours). A precipitate precipitates out of the reaction solution. This is filtered off, rinsed with water and dried, giving 0.04 g of 4-(2,3-dihydroindol-1-yl)-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)quinazoline as white solid (yield 31%, content 97%); MS-FAB (M+H+)=363.9; Rf (polar method): 1.71 min;

1. custom(HPLC check, about 24 hours)
2. customA precipitate precipitates out of the reaction solution
3. filtrationThis is filtered off
4. washrinsed with water
5. customdried