1,2,3,4-Tetrahydroisoquinoline → HCID 67516832, compound

Participants

Reaction Steps

0.75 g of 4-chloro-6-iodoquinazoline, 0.45 g of 1,2,3,4-tetrahydroisoquinoline and 0.63 ml of triethylamine in 6.0 ml of dioxane are heated at 80° C. in a flask until the quinazoline has reacted completely (HPLC check, about 3 hours). The cooled reaction solution is evaporated to dryness in a rotary evaporator. The residue is purified by means of column chromatography (gradient heptane: EA 10-100% in 20 min.), giving 0.87 g of 4-(3,4-dihydro-1H-isoquinolin-2-yl)-6-iodoquinazoline as yellowish solid (yield 90%, content 92%); MS-FAB (M+H+)=388.0; Rf (polar method): 1.84 min.

Provenance & Evidence