Trifluoroacetic acid → HCID 178432072, compound

Participants

Reaction Steps

0.25 g of 1-{6-[2-methyl-3-(2-trimethylsilanylethoxymethyl)-3H-imidazo[4,5-b]-pyridin-6-yl]quinazolin-4-yl}-2,3-dihydro-1H-quinolin-4-one and 255 μl of trifluoroacetic acid in 2 ml of dichloromethane are stirred at 25° C. in a flask until the reaction is complete (HPLC check, about 72 hours). The cooled reaction solution is evaporated to dryness in a rotary evaporator. The residue is purified by means of preparative HPLC (gradient water:acetonitrile 1-50% in 16 min.), giving 0.04 g of 1-[6-(2-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-quinazolin-4-yl]-2,3-dihydro-1H-quinolin-4-one (“A13”) as white solid (yield 23%, content 99%); MS-FAB (M+H+)=407.1; Rf (polar method): 1.50 min;

Provenance & Evidence