Dimethylformamide → HCID 66973566, compound

Participants

Reaction Steps

To an 8 mL screw-cap vial was added 4-amino-5-fluoro-1-(1-methyl-1H-imidazole-4-sulfonyl)-1H-pyrimidin-2-one (80 mg, 0.3 mmol), N,N-dimethylformamide (DMF; 3 mL), and dimethylformamide dimethylacetal (DMF-DMA; 70 mg, 0.6 mmol). The mixture was shaken at room temperature for 16 h, diluted with Et2O and filtered to yield the title product as a light yellow solid (68 mg, 69%): mp 228-232° C. dec; 1H NMR (300 MHz, DMSO-d6) δ 8.67 (s, 1H), 8.25-8.21 (m, 2H), 7.82 (s, 1H), 3.73 (s, 3H), 3.24 (s, 3H), 3.13 (s, 3H); ESIMS m/z 329 ([M+H]+).

Provenance & Evidence