Phenyl isocyanate → HCID 178521964, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-amino-5-fluoropyrimidin-2-ol (0.200 g, 1.5 mmol) in anhydrous DMF (3 mL) was added phenylisocyanate (0.251 g, 2.1 mmol) and the mixture was stirred at 23° C. for 1 h and then at 60° C. for 16 h. The reaction mixture was cooled to room temperature, and the residual solid was collected by filtration. The filter cake was washed with diethyl ether (Et2O) and dried in a vacuum oven at 40° C. for 3 h to give 1-(5-fluoro-2-hydroxypyrimidin-4-yl)-3-phenylurea as a white solid (0.210 g, 55%), which was used immediately in the next step.

Provenance & Evidence