反应详情

To a solution of benzyl 2-(cis-4-[tert-butyl(dimethyl)silyl]oxy cyclohexyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate (18.0 g, 35.9 mmol) in methanol (150 mL) was added 10% palladium on carbon (Aldrich, cat #: 520888) (1.8 g, 1.5 mmol) under the atmosphere of nitrogen. The reaction mixture was hydrogenated and shaken at 50 psi for 20 h. The reaction mixture was filtered through a pad of Celite and then washed with methanol (300 mL). The filtrate was concentrated under reduced pressure to give the desired product as a white solid in quantitative yield.

1. filtrationThe reaction mixture was filtered through a pad of Celite
2. washwashed with methanol (300 mL)
3. concentrationThe filtrate was concentrated under reduced pressure