N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide → HCID 178464738, compound

HRID 1469134Notes

Reaction equation

HRID 1469134 reaction equation
[CH2:1]([NH:3][C:4]([C:6]1[CH:11]=[CH:10][C:9](B2OC(C)(C)C(C)(C)O2)=[CH:8][N:7]=1)=[O:5])[CH3:2].Br[C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:45][CH2:44][CH2:43][C@@:30]3([C:34](=[O:35])[N:33]([C@H:36]4[CH2:41][CH2:40][C@@H:39]([OH:42])[CH2:38][CH2:37]4)[CH2:32][CH2:31]3)[CH2:29]2)=[C:24]([F:46])[CH:23]=1>>[CH2:1]([NH:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:22]2[CH:27]=[CH:26][C:25]([N:28]3[CH2:45][CH2:44][CH2:43][C@@:30]4([C:34](=[O:35])[N:33]([C@H:36]5[CH2:37][CH2:38][C@@H:39]([OH:42])[CH2:40][CH2:41]5)[CH2:32][CH2:31]4)[CH2:29]3)=[C:24]([F:46])[CH:23]=2)=[CH:8][N:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 59868917N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamideHCID 178517853HCID 178517853, compound

Product 1

HCID 178464738HCID 178464738, compound

Procedure

This compound was prepared by using procedures that were analogous to those described for the synthesis of Example 1, Step 8 starting from N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamide and (5S)-7-(4-bromo-2-fluorophenyl)-2-(cis-4-hydroxycyclohexyl)-2,7-diazaspiro[4.5]decan-1-on. LC/MS m/e 495.3 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5ca8b377278c4e4184ea9e0c9ecfda65
Source dataset
uspto-grants-2015_04
Patent number
US09006260B2

Reaction notes

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