Hydrochloric Acid → HCID 66693659, compound

Participants

Reaction Steps

To a solution of bromide 10 (9.7 g, 32.6 mmol) in CH2Cl2 (100 mL) was added boron tribromide (40 mL, 39.2 mmol, 1M in CH2Cl2) dropwise at 0° C. The mixture was warmed up to room temperature slowly and stirred at room temperature for 3 hours. To the mixture was added aq. 1N HCl solution (200 mL) dropwise at 0° C. The mixture was extracted with CH2Cl2 (150 mL×2). The combined organic layer was dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by silica column chromatography (Biotage) to provide the desired product 12 (5.64 g, 61%).

Provenance & Evidence