Boron trifluoride etherate → HCID 66691356, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of alcohol 33 (8.53 g, 10.1 mmol) in CH2Cl2 (50 mL) were added triethylsilane (3.3 mL, 20.2 mmol) and boron trifluoride diethyl etherate (2.6 mL, 20.2 mmol) at −60° C. The mixture was allowed to slowly warm to −20° C. To a mixture was added aq. saturated K2CO3 solution (50 mL) to quench the reaction. The mixture was evaporated under reduced pressure to remove CH2Cl2 and extracted with EtOAc (100 mL). The combined organic layer was dried over MgSO4, filtered, and concentrated in vacuo to yield the title compound 34 (8.22 g), which was carried on to the next step without further purification.

Provenance & Evidence