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Ethoxyacetyl chloride → 4-{[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}tetrahydro-2H-pyran-4-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethoxyacetyl chloride | HCID 84189 | — |
| 反応物 | 4-[(3-Aminoquinolin-4-ylamino)methyl]tetrahydropyran-4-ol | HCID 57457824 | — |
| 生成物 | 4-{[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}tetrahydro-2H-pyran-4-ol | HCID 57515396 | 80.2% |
反応手順
4-{[(3-Aminoquinolin-4-yl)amino]methyl}tetrahydro-2H-pyran-4-ol (7.50 g, 27.4 mmol) was reacted with ethoxyacetyl chloride (3.70 g, 30.1 mmol) and the resulting product was cyclized according to the method described in Part E of Example 9 to provide 4-{[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}tetrahydro-2H-pyran-4-ol as pale tan crystals (7.50 g, 76%) after crystallization from ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09006264B2 |
| 出典データセット | uspto-grants-2015_04 |
| ORD ID | ord-defc5e2dff304d6f8b24d620b182fb95 |
| 出典メモ | uspto-grants-2015_04 |