反应详情

温度

100 °C

A solution of 2-[3-(2-Methoxy-ethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (Step 5, 109 mg, 0.39 mmol) in THF/H2O (10:1; 3 mL) was added to a microwave vial containing 3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid pyrimidin-4-ylamide (step 4, 104 mg, 0.26 mmol) and potassium carbonate (108 mg, 0.786 mmol). Nitrogen gas was bubbled through the mixture for 5 mins then 1,1′-bis[(diphenylphosphino)-ferrocene]dichloropalladium(II) complex with CH2Cl2 (21 mg, 10 mole %) was added and the vial sealed and heated at 100° C. in microwave synthesiser for 30 min. The cooled reaction mixture was diluted with ethyl acetate (20 mL) and washed through celite (2.5 g IST cartridge). A further 10 mL of ethyl acetate was washed through the celite pad and combined filtrate was washed sequentially with water (30 mL), 1N NaOH solution (30 mL), water (30 mL) then sat. sodium chloride solution (30 mL). Mixture dried over sodium sulphate and filtered. Filtrate solvents were removed in vacuo to afford a brown gum, which was purified by flash chromatography, eluting with a gradient of 50 to 100% ethyl acetate in hexane to a afford a gummy solid. Product was dissolved in dichloromethane (25 mL) and 2N NaOH (aq, 25 mL) was added and mixture stirred vigorously for 1 h. Phases were separated and the organic layer dried over sodium sulphate, filtered and filtrate solvent removed in vacuo to leave a solid, which was triturated with diethyl ether, filtered and dried to afford the title compound as colourless solid (50 mg; 45%)

1. customNitrogen gas was bubbled through the mixture for 5 mins
2. addition1,1′-bis[(diphenylphosphino)-ferrocene]dichloropalladium(II) complex with CH2Cl2 (21 mg, 10 mole %) was added
3. customthe vial sealed
4. customThe cooled reaction mixture
5. washwashed through celite (2.5 g IST cartridge)
6. washA further 10 mL of ethyl acetate was washed through the celite pad
7. washwas washed sequentially with water (30 mL), 1N NaOH solution (30 mL), water (30 mL)
8. dry with materialMixture dried over sodium sulphate
9. filtrationfiltered
10. customFiltrate solvents were removed in vacuo
11. customto afford a brown gum, which
12. customwas purified by flash chromatography
13. washeluting with a gradient of 50 to 100% ethyl acetate in hexane to
14. customa afford a gummy solid
15. customPhases were separated
16. dry with materialthe organic layer dried over sodium sulphate
17. filtrationfiltered
18. customfiltrate solvent removed in vacuo
19. customto leave a solid, which
20. customwas triturated with diethyl ether
21. filtrationfiltered
22. customdried