Aminopyrazine → HCID 66710701, compound

HRID 1469361Notes

Reaction equation

HRID 1469361 reaction equation
[N+](C1C=CC(O[C:11]([N:13]2[CH2:16][CH:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][N:19]=3)[CH2:14]2)=[O:12])=CC=1)([O-])=O.[NH2:25][C:26]1[CH:31]=[N:30][CH:29]=[CH:28][N:27]=1>>[N:27]1[CH:28]=[CH:29][N:30]=[CH:31][C:26]=1[NH:25][C:11]([N:13]1[CH2:14][CH:15]([O:17][C:18]2[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][N:19]=2)[CH2:16]1)=[O:12]

Participants

3

Reactant 2

HCID 78747AminopyrazineHCID 580731193-(5-Bromo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

Product 1

HCID 66710701HCID 66710701, compoundYield 56.4%

Procedure

This compound was prepared by the method outlined for example 5 step 4. Thus 3-(5-bromo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester (905 mg, 2.30 mmol) was reacted with 2-aminopyrazine (243 mg, 2.53 mmol) to afford the title compound (454 mg, 56%) as off white solid.

Workup

  1. customThis compound was prepared by the method

Sources & evidence

ORD record
ord-0aa8d0a9bc7c4f70868ce0a365ef4754
Source dataset
uspto-grants-2015_04
Patent number
US09006269B2

Reaction notes

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