HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Acrylate → (E)-3-(2-methyl-benzothiazol-6-yl)-acrylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Iodo-2-methyl-1,3-benzothiazole | HCID 807592 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | (E)-3-(2-methyl-benzothiazol-6-yl)-acrylic acid methyl ester | HCID 67505787 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 6-iodo-2-methylbenzo[d]thiazole (275 mg, 1 mmol), methyl acrylate (103 mg, 1.2 mmol), diacetoxypalladium (22 mg, 0.1 mmol) and triethylamine (304 mg, 3 mmol) MeCN (8 mL) is heated in a microwave apparatus at 100° C. for 10 min. The solvent is removed under reduce pressure and the residue is purified by flash chromatography (heptane:EtOAc, 2:1) to give (E)-3-(2-methyl-benzothiazol-6-yl)-acrylic acid methyl ester. MS 234.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006249B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-c7874f8223fe480ba751f892847c0abd |
| Source note | uspto-grants-2015_04 |