Sodium Hydroxide → HCID 178524642, compound

HRID 1469666Notes

Reaction equation

HRID 1469666 reaction equation
C[O:2][C:3]([C:5]1[O:9][N:8]=[C:7]([OH:10])[CH:6]=1)=[O:4].[OH-].[Na+]>CO>[OH:10][C:7]1[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[O:9][N:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178498603HCID 178498603, compound

Product 1

HCID 178524642HCID 178524642, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-hydroxy-isoxazole-5-carboxylic acid methyl ester (286 mg, 2.0 mmol) in methanol (7 mL) is added 1N NaOH (4.0 mL, 4.0 mmol) and the mixture is stirred at room temperature for 18 hrs. The solvent is removed under reduced pressure and 4.0 mL of 1N HCl is added to the residue. The resulting solution is lyophilized to give the product which is used as is in subsequent reactions.

Workup

  1. customThe solvent is removed under reduced pressure and 4.0 mL of 1N HCl
  2. additionis added to the residue
  3. customto give the product which

Sources & evidence

ORD record
ord-2a63eb7349b04b4493c695453a530373
Source dataset
uspto-grants-2015_04
Patent number
US09006249B2

Reaction notes

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