Ammonium Chloride → 1-(3-(Trifluoromethyl)phenoxy)isoquinolin-5-amine

Participants

Reaction Steps

The title compound was prepared following the procedure described in Step 3 of Intermediate-1 using 5-nitro-1-(3-(trifluoromethyl)phenoxy)isoquinoline (200 mg, 0.59 mmol), iron powder (267 mg, 4.7 mmol), and NH4Cl (312 mg, 5.9 mmol) in EtOH (4 mL) and water (1 mL) to afford 170 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 7.79 (d, J=5.7 Hz, 1H), 7.70-7.50 (m, 6H), 7.40 (t, J=7.8 Hz, 1H), 6.93 (d, J=7.2 Hz, 1H), 6.02 (br s, 2H).

Provenance & Evidence