HCID 86692237, compound → HCID 86692236, compound

Participants

Reaction Steps

A solution of N4-(4-methoxybenzyl)-N8-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine (180 mg, 0.425 mmol) in TFA (2 mL) was stirred at 80° C. for 2 h. Then the reaction mixture was quenched with a saturated solution of NaHCO3 and was extracted with EtOAc. The organic layer was washed with water and brine, separated, dried, filtered and concentrated. The residue was triturated with Et2O to afford 120 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 8.86 (s, 1H), 8.30 (d, J=4.5 Hz, 1H), 7.66-7.43 (m, 4H), 7.38 (t, J=7.8 Hz, 1H), 7.21-7.18 (d, J=7.8 Hz, 1H), 6.83 (m, 3H), 6.60 (d, J=5.1 Hz, 1H).

Provenance & Evidence