反应详情

温度

150 °C

A mixture of 4-chloro-8-nitroquinoline (step-2, Intermediate-11, 100 mg, 0.48 mmol) and 3-(trifluoromethyl)aniline (309 mg, 1.92 mmol) was heated at 150° C. for 20 minutes in microwave. Then water was added to the reaction mixture and it was extracted with CHCl3. The organic layer was washed with brine, separated, dried, filtered and concentrated. The residue was purified by column chromatography to afford 250 mg of the title product.

1. extractionwas extracted with CHCl3
2. washThe organic layer was washed with brine
3. customseparated
4. customdried
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was purified by column chromatography