Phosphorus oxychloride → HCID 86692243, compound

Participants

Reaction Steps

To a solution of 2-methyl-8-nitroquinazolin-4(3H)-one (250 mg, 1.22 mmol) in toluene (1 mL) was added POCl3 (374 mg, 2.44 mmol) and the reaction mixture was heated at reflux for 10 h. Then the reaction mixture was concentrated and triturated with Et2O. The precipitate obtained was filtered and dried to afford 150 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 8.60-8.58 (d, J=7.8 Hz, 1H), 8.52-8.49 (d, J=9.0 Hz, 1H), 7.95-7.89 (t, J=7.8 Hz, 1H), 2.75 (s, 3H).

Provenance & Evidence