Potassium Carbonate → HCID 86692245, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Intermediate-11, step-3 using 4-chloro-8-nitroquinoline (Intermediate-11, step-2, 300 mg, 1.44 mmol), 2-fluoro-5-(trifluoromethyl)phenol (389 mg, 2.16 mmol), K2CO3 (596 mg, 4.32 mmol) in CH3CN (4 mL) to afford 432 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 8.82 (d, J=4.8 Hz, 1H), 8.60 (d, J=8.4 Hz, 1H), 8.36 (d, J=7.5 Hz, 1H), 8.11 (d, J=5.7 Hz, 1H), 7.86-7.75 (m, 3H), 6.93 (d, J=4.8 Hz, 1H); MS (m/z): 353.21 (M+H)+.

Provenance & Evidence