Ammonium Chloride → HCID 86692247, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Step 3 of Intermediate-1 using 1-(2-fluoro-5-(trifluoromethyl)phenoxy)-5-nitroisoquinoline (320 mg, 0.90 mmol), iron powder (500 mg, 9.09 mmol), and NH4Cl (389 mg, 7.2 mmol) in EtOH (8 mL) and water (2 mL) to afford 230 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 7.89 (d, J=5.7 Hz, 1H), 7.75-7.59 (m, 4H), 7.50 (d, J=7.8 Hz, 1H), 7.40 (t, J=8.1 Hz, 1H), 6.93 (d, J=7.5 Hz, 1H), 6.03 (s, 2H); MS (m/z): 323.28 (M+H)+.

Provenance & Evidence