Ammonium Chloride → HCID 86692254, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Intermediate-1, step-2 using N-(2-fluoro-4-(trifluoromethyl)phenyl)-5-nitroisoquinolin-1-amine (190 mg, 0.54 mmol), iron powder (303 mg, 5.41 mmol), and NH4Cl (232 mg, 4.32 mmol) in EtOH:H2O (3:1, 4 mL) to afford 120 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 8.93 (s, 1H), 7.89 (t, J=8.4 Hz, 1H), 7.82 (d, J=6.0 Hz, 1H), 7.64 (d, J=10.8 Hz, 1H), 7.51 (t, 8.4 Hz, 2H), 7.40 (d, J=6.0 Hz, 1H), 7.30 (t, J=7.8 Hz, 1H0, 6.84 (d, J=7.2 Hz, 1H), 5.83 (s, 2H); MS (m/z): 322.33 (M+H)+.

Provenance & Evidence