4-(Trifluoromethyl)aniline → HCID 71678546, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Intermediate-1, step-2 using 1-chloro-5-nitroisoquinoline (Intermediate-1, step-1, 500 mg, 2.30 mmol), and 4-(trifluoromethyl)aniline (772 mg, 4.70 mmol) in N-methylpyrrolidinone (3 mL) to afford 750 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 9.83 (s, 1H), 8.94 (d, J=8.4 Hz, 1H), 8.53 (d, J=7.2 Hz, 1H), 8.26 (d, J=6.3 Hz, 1H), 8.06 (d, J=9.0 Hz, 2H), 8.33 (t, J=7.8 Hz, 1H), 7.66 (m, 3H); MS (m/z): 334.19 (M+H)+.

Provenance & Evidence