Ammonium Chloride → HCID 86692255, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Intermediate-1, step-3 using 5-nitro-N-(4-(trifluoromethyl)phenyl)isoquinolin-1-amine (750 mg, 2.25 mmol), iron powder (1.26 g, 22.5 mmol), and NH4Cl (963 mg, 18.0 mmol) in EtOH—H2O (5:2, 7 mL) to afford 260 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 9.27 (s, 1H), 8.09 (d, J=9.0 Hz, 2H), 7.94 (d, J=6.0 Hz, 1H), 7.64 (m, 3H), 7.44 (d, J=5.7 Hz, 1H), 7.33 (t, J=7.8 Hz, 1H), 6.87 (d, J=7.8 Hz, 1H), 5.87 (br s, 2H); MS (m/z): 304.28 (M+H)+.

Provenance & Evidence