Ammonium Chloride → HCID 86692257, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Step 3 of Intermediate-1 using 5-nitro-1-(4-(trifluoromethyl)phenoxy)isoquinoline (800 mg, 2.39 mmol), iron powder (1.34 g, 23.9 mmol), and NH4Cl (1.02 g, 19.1 mmol) in EtOH (5 mL) and water (1 mL) to afford 140 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 7.81 (m, 3H), 7.72 (d, 1H), 7.46-7.40 (m, 4H), 6.94 (d, J=6.9 Hz, 1H), 6.03 (s, 2H); MS (m/z): 305.17 (M+H)+.

Provenance & Evidence