Ammonium Chloride → HCID 71678548, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Step 3 of Intermediate-1 using 1-(4-fluoro-3-(trifluoromethyl)phenoxy)-5-nitroisoquinoline (830 mg, 2.35 mmol), iron powder (1.31 mg, 23.5 mmol), and NH4Cl (1.09 g, 18.8 mmol) in EtOH (8 mL) and water (2 mL) to afford 660 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 7.79 (d, J=6.0 Hz, 1H), 7.71-7.56 (m, 4H), 7.51 (d, J=8.1 Hz, 1H), 7.40 (t, J=8.1 Hz, 1H), 6.94 (d, J=7.2 Hz, 1H), 6.01 (s, 2H).

Provenance & Evidence