Potassium Carbonate → 4-(4-Fluoro-3-(trifluoromethyl)phenoxy)-8-nitroquinoline

Participants

Reaction Steps

The title compound was prepared following the procedure described in Intermediate-11, step-3 using 4-chloro-8-nitroquinoline (Intermediate-11, step-2, 250 mg, 1.20 mmol), 4-fluoro-3-(trifluoromethyl)phenol (430 mg, 2.40 mmol), K2CO3 (479 mg, 3.60 mmol) in CH3CN (5 mL) to afford 380 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 10.75 (s, 1H), 8.82 (d, J=5.4 Hz, 1H), 7.92 (m, 1H), 7.86-7.81 (m, 3H), 7.31 (t, J=9.6 Hz, 1H), 6.90 (d, J=5.1 Hz, 1H); MS (m/z): 353.14 (M+H)+.

Provenance & Evidence