HCID 86692243, compound → HCID 86692259, compound

Participants

Reaction Steps

A solution of 4-chloro-2-methyl-8-nitroquinazoline (Intermediate-27, step-2, 100 mg, 0.45 mmol) in isopropylamine (1 mL) was heated at reflux for 30 mins. Then the reaction mixture was diluted with water and was extracted with ethyl acetate. The organic layer was washed with brine, separated, dried, filtered and concentrated. The residue was purified by column chromatography to afford 60 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 8.54-8.51 (d, J=8.4 Hz, 1H), 8.23-8.21 (d, J=7.5 Hz, 1H), 8.17-8.14 (d, J=7.8 Hz, 1H), 7.56-7.51 (t, J=7.8 Hz, 1H), 4.58-4.51 (m, 1H), 2.44 (s, 3H), 1.27 (s, 3H), 1.25 (s, 3H).

Provenance & Evidence