Tert-Butylamine → HCID 86692260, compound

Participants

Reaction Steps

A solution of 4-chloro-8-nitroquinazoline (Intermediate-7, step-2, 500 mg, 2.39 mmol), and tert-butylamine (350 mg, 4.78 mmol) in pyridine (5 mL) was stirred at rt for 3 h. Then the reaction mixture was concentrated and the residue was dissolved in EtOAc. Then the solution was washed with water and brine, separated, dried, filtered, concentrated and purified by column chromatography to afford 300 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 8.67 (d, J=8.4 Hz, 1H), 8.53 (s, 1H), 8.22 (d, J=7.8 Hz, 1H), 7.74 (s, 1H), 7.63-7.58 (t, J=8.0 Hz, 1H), 1.54 (s, 9H); MS [M+H]+: 247.18.

Provenance & Evidence