Sodium Hydroxide → 6-Chloro-2-fluoro-3-((3-hydroxy-2,2-dimethylpropanamido)methyl)benzoic acid

Participants

Reaction Steps

The title compound was prepared following the procedure described in Step 3 of Intermediate-2 using ethyl 6-chloro-2-fluoro-3-((3-hydroxy-2,2-dimethylpropanamido)methyl)benzoate (712 mg, 2.15 mmol) in THF:MeOH:H2O (2:1:1; 8 mL) and NaOH (344 mg, 8.60 mmol) to afford 510 mg of the title product. 1H NMR (400 MHz, DMSO-d6): δ 8.08-8.05 (t, J=8.0 Hz, 1H), 7.36-7.33 (m, 2H), 4.90 (t, 1H), 4.29-4.28 (d, J=6.0 Hz, 2H), 3.38 (m, 2H), 1.06 (s, 6H).

Provenance & Evidence