HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyryl chloride → Ethyl 6-chloro-2-fluoro-3-(isobutyramidomethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl 3-(aminomethyl)-6-chloro-2-fluorobenzoate | HCID 58483233 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 6-chloro-2-fluoro-3-(isobutyramidomethyl)benzoate | HCID 86692264 | 76.7% |
Reaction Steps
The title compound was prepared following the procedure described in Intermediate-2, step-2 using ethyl 3-(aminomethyl)-6-chloro-2-fluorobenzoate (Intermediate-2, step-1, 1.00 g, 4.32 mmol), isobutyryl chloride (690 mg, 6.48 mmol) and DIPEA (1.67 g, 12.96 mmol) in THF (30 mL) to afford 1.0 g of the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006257B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-c29d800a3fc84559b971f350d067a031 |
| Source note | uspto-grants-2015_04 |