Sodium Hydroxide → 6-Chloro-2-fluoro-3-(isobutyramidomethyl)benzoic acid

Participants

Reaction Steps

The title compound was prepared following the procedure described in Intermediate-2, step-3 using ethyl 6-chloro-2-fluoro-3-(isobutyramidomethyl)benzoate (1.00 g, 3.31 mmol) and NaOH (530 mg, 13.26 mmol) in THF:MeOH:H2O (3:2:1; 12 mL) to afford 800 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 14.10 (s, 1H), 8.32 (br t, 1H), 7.38-7.29 (m, 2H), 4.25 (d, J=5.1 Hz, 2H), 2.40 (m, 1H), 1.00 (d, J=6.9 Hz, 6H).

Provenance & Evidence