Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalyl chloride → 2-Chloro-N-(4-((4,4-difluorocyclohexyl)amino)quinazolin-8-yl)-5-(pivalamidomethyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Chloro-5-[(2,2-dimethylpropanamido)methyl]benzoic acid | HCID 58483208 | — |
| 반응물 | N4-(4,4-difluorocyclohexyl)quinazoline-4,8-diamine | HCID 86692230 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Chloro-N-(4-((4,4-difluorocyclohexyl)amino)quinazolin-8-yl)-5-(pivalamidomethyl)benzamide | HCID 86692277 | 21.9% |
반응 단계
The title compound was prepared following the procedure described in Example-1 using N4-(4,4-difluorocyclohexyl)quinazoline-4,8-diamine (Intermediate-9, 60 mg, 0.215 mmol), 2-chloro-5-(pivalamidomethyl)benzoic acid (Intermediate-5, 116 mg, 0.431 mmol), oxalyl chloride (81 mg, 0.65 mmol), DMF (1 drop) and DIPEA (84 mg, 0.65 mmol) in CH2Cl2 (3 mL) to afford 25 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 10.13 (s, 1H), 8.71 (d, 1H), 8.49 (s, 1H), 8.19 (m, 2H), 8.05 (d, 1H), 7.57-7.54 (m, 3H), 7.41 (d, 1H), 4.41 (m, 1H), 4.31 (d, 2H), 2.00 (m, 6H), 1.75 (m, 2H), 1.12 (s, 9H); MS (m/z): 530.20 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09006257B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-0d000e661d984affb9d5e963f35c1d2a |
| 출처 메모 | uspto-grants-2015_04 |