Oxalyl chloride → HCID 86692291, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example-1 using 1-((4,4-dimethylcyclohexyl)oxy)isoquinolin-5-amine (Intermediate-28, 70 mg, 0.25 mmol), 6-chloro-2-fluoro-3-(pivalamidomethyl)benzoic acid (Intermediate-2, 89 mg, 0.31 mmol), oxalyl chloride (59 mg, 0.47 mmol), DMF (1 drop) and DIPEA (97 mg, 0.75 mmol) in CH2Cl2 (3 mL) to afford 45 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 10.89 (s, 1H), 8.19 (t, 1H), 8.14 (d, J=8.4 Hz, 1H), 8.04 (d, J=5.7 Hz, 1H), 7.95 (d, J=7.8 Hz, 1H), 7.67 (t, J=7.8 Hz, 1H), 7.48 (d, J=6.0 Hz, 1H), 7.43 (s, 1H), 7.37 (d, J=7.8 Hz, 1H), 5.28 (m, 1H), 4.34 (d, J=5.4 Hz, 2H), 1.90 (m, 2H), 1.78 (m, 2H), 1.53 (m, 2H), 1.34 (m, 2H), 1.15 (s, 9H), 1.00 (s, 3H), 0.97 (s, 3H); MS (m/z): 540.10 (M+H)+.

Provenance & Evidence