Oxalyl chloride → HCID 71679391, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example-1 using 4-(2-fluoro-5-(trifluoromethyl)phenoxy)quinolin-8-amine (Intermediate-35, 100 mg, 0.31 mmol), 6-chloro-2-fluoro-3-(pivalamidomethyl)benzoic acid (Intermediate-2, 133 mg, 0.46 mmol), oxalyl chloride (187 mg, 0.69 mmol), DMF (1 drop) and DIPEA (120 mg, 0.93 mmol) in CH2Cl2 (4 mL) to afford 80 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 10.74 (s, 1H), 8.78 (d, J=7.8 Hz, 1H), 8.70 (d, J=5.4 Hz, 1H), 8.11-8.05 (m, 3H), 7.83-7.71 (m, 3H), 7.41-7.30 (m, 2H), 6.83 (d, J=4.8 Hz, 1H), 4.29 (d, J=5.4 Hz, 2H), 1.12 (s, 9H); MS (m/z): 592.33 (M+H)+.

Provenance & Evidence