Oxalyl chloride → HCID 71679561, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example-1 using N1-(2-fluoro-4-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine (Intermediate-39, 80 mg, 0.24 mmol), 2-chloro-5-(pivalamidomethyl)benzoic acid (Intermediate-5, 134 mg, 0.49 mmol), oxalyl chloride (93 mg, 0.74 mmol), DMF (1 drop) and DIPEA (93 mg, 0.72 mmol) in CH2Cl2 (5 mL) to afford 25 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 10.62 (s, 1H), 9.38 (s, 1H), 8.35 (d, J=8.4 Hz, 1H), 8.21 (t, 1H), 8.00-7.93 (m, 2H), 7.88 (t, J=7.5 Hz, 1H), 7.71 (d, J=9.3 Hz, 2H), 7.60-7.53 (m, 3H), 7.44 (d, J=5.7 Hz, 1H), 7.36 (d, J=9.0 Hz, 1H), 4.32 (d, J=5.4 Hz, 2H), 1.14 (s, 9H); MS (m/z): 573.29 (M+H)+.

Provenance & Evidence