Oxalyl chloride → HCID 71679563, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example-1 using 1-(4-fluoro-3-(trifluoromethyl)phenoxy)isoquinolin-5-amine (Intermediate-42, 80 mg, 0.24 mmol), 2-chloro-5-(pivalamidomethyl)benzoic acid (Intermediate-5, 134 mg, 0.49 mmol), oxalyl chloride (93 mg, 0.74 mmol), DMF (1 drop) and DIPEA (93 mg, 0.72 mmol) in CH2Cl2 (5 mL) to afford 26 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 10.75 (s, 1H), 8.30 (d, 1H), 8.21 (t, 1H), 8.08 (d, J=7.5 Hz, 1H), 7.98 (d, J=6.3 Hz, 1H), 7.82-7.55 (m, 7H), 7.37 (d, J=8.4 Hz, 1H), 4.32 (J=5.4 Hz, 2H), 1.14 (s, 9H); MS (m/z): 574.22 (M+H)+.

Provenance & Evidence