Oxalyl chloride → HCID 71679878, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example-1 using 4-isopropoxyquinazolin-8-amine (Intermediate-52, 100 mg, 0.49 mmol), 6-chloro-2-fluoro-3-(pivalamidomethyl)benzoic acid (Intermediate-2, 184 mg, 0.64 mmol), oxalyl chloride (87 mg, 0.69 mmol), DMF (1 drop) and DIPEA (571 mg, 1.48 mmol) in CH2Cl2 (5 mL) to afford 40 mg of the title product. 1H NMR (400 MHz, DMSO-d6): δ 10.73 (s, 1H), 8.78 (s, 1H), 8.76 (s, 1H), 8.15-8.12 (t, J=5.2 Hz, 1H), 7.87 (d, J=8.4 Hz, 1H), 7.69-7.65 (t, J=8.0 Hz, 1H), 7.37 (d, J=8.4 Hz, 1H), 7.32-7.28 (t, J=8.0 Hz, 1H), 5.60-5.54 (m, 1H), 4.28 (d, J=6.0 Hz, 2H), 1.42 (d, J=6.0 Hz, 6H), 1.11 (s, 9H); MS (m/z): 473.11 (M+H)+.

Provenance & Evidence