HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → HCID 178495781, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Hexahydro-2,5-methanopentalene-3a(1H)-carboxylic acid | HCID 2733865 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Edukt | 5-(4-fluoro-benzyl)-3-(2-methoxyethyl)-3H-thiazol-2-ylidene-amine | HCID 66859070 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | HCID 178495781 | HCID 178495781 | — |
Reaktionsschritte
A mixture of the product of Example 44A (342 mg, 1.29 mmol), hexahydro-2,5-methano-pentalene-3a-carboxylic acid (256 mg, 1.54 mmol), HATU (737 mg, 1.24 mmol) and triethylamine (1.08 mL, 7.74 mmol) in 20 mL of DMF was processed according to the method of Example 43B to afford the title compound: 1H NMR (500 MHz, DMSO-d6) δ 1.51-1.61 (m, 4H) 1.65-1.74 (m, 4H) 2.07 (d, J=9.2 Hz, 2H) 2.22-2.26 (m, 2H) 2.51-2.53 (m, 1H) 3.24 (s, 3H) 3.66 (t, J=5.3 Hz, 2H) 3.98 (s, 2H) 4.23 (t, J=5.3 Hz, 2H) 7.16-7.22 (m, 3H) 7.23 (s, 1H) 7.29-7.38 (m, 2H); MS (DCI/NH3) m/z 415 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09006275B2 |
| Quelldatensatz | uspto-grants-2015_04 |
| ORD ID | ord-346f5172dcbd4ca6a6285f9167ffd75e |
| Quellennotiz | uspto-grants-2015_04 |