2-Amino-4,5-dimethyl-1,3-thiazole → HCID 66858466, compound

HRID 1469971Notes

Reaction equation

HRID 1469971 reaction equation
[Br:1][CH2:2][CH2:3][O:4][C:5]1[C:14]2[O:13][CH2:12][CH2:11][O:10][C:9]=2[CH:8]=[CH:7][CH:6]=1.[CH3:15][C:16]1[N:17]=[C:18]([NH2:22])[S:19][C:20]=1[CH3:21]>>[BrH:1].[O:10]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([O:4][CH2:3][CH2:2][N:17]3[C:16]([CH3:15])=[C:20]([CH3:21])[S:19][C:18]3=[NH:22])[C:14]=2[O:13][CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 27355665-(2-bromoethoxy)-2,3-dihydro-1,4-benzodioxine

Product 1

HCID 66858466HCID 66858466, compoundYield 13%

Conditions

Temperature
85 °C

Procedure

A mixture of 5-(2-bromoethoxy)-2,3-dihydro-benzo[1,4]dioxine (1.2 g, 4.7 mmol) and 4,5-dimethyl-thiazol-2-ylamine (0.50 g, 3.9 mmol) was heated at 85° C. for 7 hours. The mixture was cooled to ambient temperature and the residue was recrystallized from ethanol to provide 0.18 g (13%) of the title compound.

Workup

  1. temperatureThe mixture was cooled to ambient temperature
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-a46b5d1e1af34295840f373f45890132
Source dataset
uspto-grants-2015_04
Patent number
US09006275B2

Reaction notes

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