2-Amino-4,5-dimethyl-1,3-thiazole → 4,5-dimethyl-3-[2-(2,2,2-trifluoro-ethoxy)-ethyl]-3H-thiazol-2-ylideneamine hydrobromide

HRID 1469975Notes

Reaction equation

HRID 1469975 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[Br:9][CH2:10][CH2:11][O:12][CH2:13][C:14]([F:17])([F:16])[F:15]>>[BrH:9].[CH3:1][C:2]1[N:3]([CH2:10][CH2:11][O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[C:4](=[NH:8])[S:5][C:6]=1[CH3:7]

Participants

3

Reactant 2

HCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 198289712-(2-Bromoethoxy)-1,1,1-trifluoroethane

Product 1

HCID 668592714,5-dimethyl-3-[2-(2,2,2-trifluoro-ethoxy)-ethyl]-3H-thiazol-2-ylideneamine hydrobromide

Conditions

Temperature
65 °C

Procedure

4,5-Dimethyl-thiazol-2-ylamine and 2-(2-bromo-ethoxy)-1,1,1-trifluoroethane were mixed and heated at 65° C. for 4 hours. The residue was triturated with hexane to afford the title compound. MS (ESI+) m/z 255 (M+H)+.

Workup

  1. customThe residue was triturated with hexane

Sources & evidence

ORD record
ord-4ff5218ef4274f2c97e0c93475d3b49b
Source dataset
uspto-grants-2015_04
Patent number
US09006275B2

Reaction notes

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