1-Adamantanecarboxylic acid → HCID 178435121, compound

Participants

Reaction Steps

4,5-Dimethylthiazol-2-ylamine, 3-(2-bromo-ethyl)-1H-indole and 1-adamantane carboxylic acid were processed according to the method of Example 47 to afford the title compound. 1H NMR (CDCl3, 500 MHz) δ ppm 1.68-1.75 (m, 6H) 1.91 (d, J=2.50 Hz, 6H) 1.98-2.04 (m, 3H) 2.13 (d, J=4.68 Hz, 6H) 3.04-3.21 (m, 2H) 4.20-4.43 (m, 2H) 6.98 (t, J=7.49 Hz, 1H) 7.09 (t, J=7.64 Hz, 1H) 7.17 (d, J=2.18 Hz, 1H) 7.36 (d, J=8.11 Hz, 1H) 7.68 (d, J=7.80 Hz, 1H) 10.88 (s, 1H); MS (ESI) m/z 434 (M+H)+.

Provenance & Evidence