HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Adamantanecarboxylic acid → HCID 178435117, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Adamantanecarboxylic acid | HCID 13235 | — |
| Reactant | 2-Amino-4,5-dimethyl-1,3-thiazole | HCID 73238 | — |
| Reactant | 2-Chloro-6-fluorobenzyl bromide | HCID 2773625 | — |
| Product | HCID 178435117 | HCID 178435117 | — |
Reaction Steps
4,5-Dimethylthiazol-2-ylamine, 2-bromomethyl-1-chloro-3-fluorobenzene and 1-adamantane carboxylic acid were processed according to the method of Example 47 to afford the title compound. 1H NMR (CDCl3, 500 MHz) δ ppm 1.50-1.70 (m, 12H) 1.80-1.93 (m, 3H) 2.17 (s, 3H) 2.22 (s, 3H) 5.42 (s, 2H) 7.11-7.22 (m, 1H) 7.26-7.41 (m, 2H); MS (ESI) m/z 433 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006275B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-2fb5f2f452874459b0ff7bc2a69c9456 |
| Source note | uspto-grants-2015_04 |